Depends on how the people are accessing it.
If it's via PPES, you can kill or disable the cube, if it's via client then no.
With 7.1 and a manual build, Transformer detects if the cube is locked, and gives the user an option of saving the new cube with a different name.
Either way, if you think you need to rebuild production cubes during hours of access, then it's best to build to one location and then copy the cube to the access location on a quiet system.
There's been a couple of threads on disabling cubes in PPES in the last 6m or so.
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