Depends on how much traffic you have on your mail, I've had clients that did back up during business hours. But there are rumors floating around that MWL are a little slow to lite although I've never seen it.
If you have heavy traffic a would schedule the automic backup after hours
you can back up mer mail any time, back ups are usually done after hrs so admins can still programm in mail during the day, no this should not ever slow you system down
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