Thanks for feedback Jeff.
First I agree with you that Issue Number would be used as a lookup number to get back to the specific Issue description. In this usage, the autonumber does provide a unique id number - there is only one autonumber for each issue (no duplicates).
But, when we start talking about "meaning" I think of an ID number that provides clue as to the Issue. For example, you could create issue numbers that are alphnumeric with (say) the first character(s) refering to a class or category of issues, and the last part of the unique ID being numeric (1 to infinitity) depending on how many issues exist within a category.
So, if you just need a unique ID, then autonumber is fine. If you want to start the autonumber at 1 for some reason other than having just a unique number (e.g. want the ID number to at least not misresent how many issues there are), then option 2 is re-start the numbers by appending to a new table. Option 3 is to create an ID number that has embedded meaning it it as example above.
Jeff L