Run network monitor on your server when the traffic is heavy, take a capture and if there are a number of arp broadcasts running incramental through your IP address scope then you have got a virus on the sending machine, if you suspect this is the case check for the following registry keys
HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services
RpcPatch
RpcTftpd
If you have these then you will need to run the clean up tool, check out this link:
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