The 'current' thinking within the Relational Database Gurus is that deep is better than wide. Your schema 'looks like' the wide approach.
Taking the test grades item, your outline is like the conventional teacher's grade book, listing the student's entire grade history in the single record, with a column for each possible grade. The 'modern' relational db would approach each grade as an individual record, listing the [Student], [Date], [Grade]and (possibly) an [identifier] (description of the grade item - e.g. 'Test A'.
Similar approaches can (should) be utilized on many 'groups' of fields in your db. You are probably correct in thinking that splitting 4K FIELDS into sub records with a 1:1 relationship will run into some problems. Even the 'industrial strength' relational dbs have limits on the numbner of fields allowed in a recordset. Ms. A.'s limit (which is a fairly common one) is 255 -with a caveat- that indicies, sorts, relationships, having & where 'fields' count toward the limit. There may be *are?) others 'counters', so construction of a recordset of 4K fields in most any manner will be QUITE a challenge.
I would suggest some review of realtional database strategies before starting this process. Another suggestion is to review the purposes of the information to be collected. Back to the old school "Who, What, When, Where, and Why" of each item of information. I would expect that such a review would reasonably reveal 'logical' groupings of the information which aid the development.
One approach might be to start with the 'output'. the reports (and possibly Forms) which the various users will actually use in their daily work. For each group (or even individual), define the subset of information they will utilize. Based on this, develop the various tables as groups of related information which are commonly accessed.
From the question posted, I assume that you have little experience in relational database use or programming and, frankly, think that you will be jumping into the deep end of the pool. While there are many helpful resources, I would not suggest that you rely on public bullitin board sites to get you through this project. It is -in my opinion- well beyond what a novice should be attempting. I do not know your total situation, but unless refusal would -by itself- be a dire consequence, you need to garner some experience on smaller projects before attempting this.
MichaelRed
m.red@att.net
Searching for employment in all the wrong places