This appears to have been the problem:
The bulk of the messages in the queue were from NDR's. The NDR's were generated from spoofed addresses and we could not send the NDR. The system was set up to try at 1 min then 2 then three for a total of 12 hours. This has never been a problem for us...
Under Default Domain Policy[...]Policy
User Configuration
Administrative Templates
System
Code Signing for device drivers
Determines how the system responds when a user tries to install device driver files that are not digitally signed.
When you enable this policy, use the drop-down box to...
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