It also depends on your cisco firewall topology. does your PIX have more then an inside and outside interface? Depending on model you can have up to 8. If so then put your front end server in a DMZ on the PIX and nat the DMZ to the outside opening only the ports needed ( SMTP, HTTP, POP3...
question 1: Is this happening on the inside as well as the outside of your network?
question 2: When you say nothing happens do you mean that when you hit the reply button to a message that a new window opens with no content but an IIS error?
question 3:Are you running IIS lockdown?
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