I would totally agree that Messaging Architects M+Guardian technology can do a better job. But based on Messaging Architects #'s, when I had them run me a quote on a system, I could not justify the cost to my superiors. Being an educational facility all monies are watched by the bean counters...
I will assume (and I hate to assume) that the list of addresses you have is in either a csv, txt or xml format. If so I know of no GW function that will import this list for you. I've used a 3rd party app from Toffa that will allow you to perform this task. Again, only if the files are in a csv...
We use Sophos for our desktop and servers. So I can't remark on their GW spam/virus product.
We use Barracuda as our spam/virus firewall. And have been for over 3 years. Pound for pound one of the best for the price. And we receive in over 300k pieces of mail a day. We get a spam stoppage rate...
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