Couple of things to check:
1. Can you telnet to port 110? If not then the port is closed or not accepting connections for some reason.
2. What kind of info is in the logs? Is there any indication that the mail is being accepted and queued by the server?
3. Bounce backs can tell the whole story...
Taken from Microsofts Knowledge Base:
XFOR: Restricting Routing in the Internet Mail Service
(Q196626)
The information in this article applies to:
· Microsoft Exchange Server, version 5.5
SYMPTOMS
The Exchange Server Internet Mail Service (IMS) allows you to configure the server
to allow mail...
Make sure that your domain registration has not expired. On a daily basis I come across clients who are running a mail server and come to find out, their domain registration had run out. The symptom you are describing, where you are able to send and receive internally fine, however sending out...
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