I used to work for Lotus. I now do Exchange administration. I also do Domino administration. I'm biased in both directions.
If you want straight-forward, easy to use, easy to administer, simple yet rich e-mail, Exchange is your answer. However, if you need good back-end connectivity, work flow, or mail integration with databases, you can't beat Domino.
Domino administration isn't easy. There is a lot to learn, and it can be frustrating. However, you can do some seriously cool things with the Lotus suite. Lotus also gives you a lot more in terms of server platforms. I'd never run my internet e-mail on an NT server. With Exchange, you don't have a choice.
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