By default, when a user enables OOF, and OOF is generated when the user's email address is listed in the TO, CC, or BCC fields of a message. Since most mailing lists put all the addresses in the BCC field, you might find it useful to disable OOF replies to messages in which the user's email address was in the BCC field.
To do so, add this registry entry to the server hosting the mailboxes that you want to disable BCC OOF responses on:
HKLM\System\CurrentControlSet\Services\MSExchangeIS\ParametersSystem
Value: SuppressOOFsToDistributionLists
Type: Reg_DWORD
Value Data: 1
Note that this will only disable OOF if the TO and/or CC fields have at least one address in them. If the only field with addresses in it is the BCC field, then the OOF will still trigger, regardless of this registry entry.
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