One more thing that really important, make sure all your drives on the host you are targeting for backups have drive letters associated with them. Windows 2008 R2 servers creates a system reserve disk without a drive letter if not the VADP process with continue to perform fulls but will not...
You will need communication with the Vcenter host documentation states that you should create a client for you Vcenter host in networker but you do not have to back it up just needs to be present under clients.
You do not need to install a client on any of the machines you plan on backing up...
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